Coenzyme Q10 Recommended for Advanced Maternal Age Conception: Benefits During IVF USA

2024-06-25 20:09:39，visits： 228

Many women of advanced maternal age receive advice from doctors before attempting conception or undergoing IVF: prioritize lifestyle factors, ensure adequate rest, moderate exercise, balanced diet, maintain a positive mindset, undergo necessary examinations, and lastly, supplement with folic acid and coenzyme Q10. So, what is coenzyme Q10, and what specific benefits does it offer during pregnancy?

Coenzyme Q10 is a lipid-soluble quinone compound present in all cells of the human body, crucial for energy production processes. It is particularly abundant in organs like the heart, liver, and pancreas, primarily located within mitochondria. Without coenzyme Q10, the body cannot generate ATP (adenosine triphosphate), which is essential for energy supply.

Coenzyme Q10 exhibits significant antioxidant properties, combating oxidative damage from free radicals, promoting cell growth, self-repair, enhancing antioxidant capacity, delaying aging, and improving immunity, with positive effects on ovarian function in women. For follicular development, energy metabolism is crucial throughout the developmental process, playing an irreplaceable role. Cells can only complete meiosis with sufficient ATP energy. However, mitochondrial function declines in many infertile women of advanced age, with increased oxidative stress leading to decreased egg quality.

Research indicates that a lack of coenzyme Q10 significantly affects mitochondrial function and cellular vitality. Elevated oxidative stress due to increased free radicals in older women reduces egg quality, leading to increased rates of aneuploidy and fewer functionally intact mitochondria in eggs. Embryos originate from the union of sperm and egg cells, with egg cells being the largest human cell, reliant entirely on mitochondrial metabolism. Therefore, egg mitochondrial quality determines embryo quality and offspring health.

A deficiency in coenzyme Q10 lowers ATP levels, increasing the occurrence of oxidative stress responses. Only when ATP levels reach 2 pmol or higher can fertilized eggs easily implant and continue to develop. Insufficient ATP content can obstruct egg cell development, decrease embryo activity and implantation rates, thereby lowering pregnancy rates and increasing the risk of natural miscarriage. Moreover, oxidative stress is associated with various female reproductive disorders, contributing to difficulties in conception and infertility.

Oxidative damage is also a significant factor leading to decreased sperm quality and increased DNA fragmentation in males. Coenzyme Q10's antioxidant action significantly impacts the health of the male reproductive system. Therefore, supplementing with coenzyme Q10 improves egg and sperm quality, serving as an adjunctive therapy for infertility patients to enhance fertility.

With advancing age, environmental factors, and lifestyle pressures, infertility issues are increasing annually. Currently, one in eight couples faces infertility issues, with this trend skewing towards younger ages. As an effective assisted reproductive technology, IVF-PGT (Preimplantation Genetic Testing) has become a crucial choice for most infertile couples. IVF-PGT involves fertilization in a laboratory setting followed by embryo transfer into the mother's uterus for continued development. Today, many capable families opt for IVF in the United States, primarily for its embryo PGS testing technology and experienced doctors. IVF USA offers higher success rates and reduces instances of repeated failed transfers.

For any inquiries or more detailed information about IVF technology, please contact IVF USA. Currently, IVF USA provides services including egg freezing, IVF, and third-party reproduction to those in need, expanding operations beyond the US to include Japan for IVF and egg freezing, Thailand for IVF and egg freezing, as well as Mexico, Taiwan, and Hong Kong. Collaborating closely with leading IVF specialists worldwide, our expert team is here to provide professional advice and support, helping you achieve your dream of parenthood sooner.