Is it possible to directly transfer embryos without undergoing PGS/PGD screening for someone over 40? Dr. Nathan Zhang from IVF USA discusses IVF in the US and in Thailand

2024-01-17 19:59:00，visits： 389

When exploring the topic of American IVF, we must address a highly debated question: for women over 40, is it necessary to conduct PGS testing on embryos, and can they be forcefully transplanted? This is a crucial issue related to reproductive success, especially for women in their 40s, as it determines whether they can smoothly welcome the arrival of a healthy baby.

Once, a female friend shared an experience with me. She consulted a domestic expert who told her that PGS testing for women over 40 is not very meaningful because the results are usually abnormal. Direct transplantation might offer a glimmer of hope. This made her think that maybe she could give it a try, especially since last year, PGS testing on her three blastocysts all showed abnormalities, and she was already 40 at that time.

With the questions raised by this friend, I interviewed Dr. Nathan Zhang, an expert in the field of assisted reproduction and the founder of IVF USA.

Dr. Zhang pointed out that the quantity and quality of a woman's eggs are closely related to her age. As age increases, the number of eggs decreases, and their quality declines, leading to an increased probability of chromosomal abnormalities in embryos. If a woman is over 40 and undergoes embryo transplantation without PGS testing, it is likely to result in failure. If pregnancy occurs after transplantation but ends in a miscarriage due to chromosomal abnormalities, a uterine cleaning surgery will be required, taking several months for the uterus to recover. For women in their 40s, this means losing more opportunities for fertility.

Regarding the question of whether embryos with abnormal PGS test results can lead to successful live births, Dr. Zhang pointed out that sometimes, when chromosomal abnormalities are detected in the nourishing outer layer of the embryo but the inner cell mass is normal, success may be possible. However, due to the limited samples in such cases, there is currently no related research report. Therefore, it is not recommended to risk transplanting blastocysts with abnormal PGS results. This practice is akin to gambling, with a minimal chance of success. Once it fails, it not only wastes time but also inflicts significant harm to the body. Women at the age of 40 cannot afford such risks!

Whether it's PGS or PGD, the entire process requires extracting 6-8 cells from a complete blastocyst, and the doctor's skill is crucial. In addition, excellent doctors can adjust personalized plans based on different ages, ovarian function, and drug responses, increasing the success rate of ovulation induction. The success of American IVF is closely related to the level of doctors and laboratories. Performing PGS/PGD screening while protecting embryos, excluding abnormalities, significantly increases the success rate of transplantation.

35 years old is a crucial turning point for women's fertility. According to the latest data from the United States, women under 35 with 15 eggs retrieved in one cycle achieve an 85% live birth rate for IVF. In contrast, women aged 36 and above, with 15 eggs retrieved in one cycle, only have a 36% live birth rate for IVF. In short, as women's age increases, their fertility decreases, which is an indisputable fact. Therefore, Dr. Zhang advises women to take action early, whether it's freezing eggs in the USA or undergoing IVF in the USA.

Currently, IVF USA provides services such as egg freezing, IVF, and third-party reproductive assistance for those in need. The business has expanded to countries outside the USA, including Japan for IVF and egg freezing, Thailand for IVF and egg freezing, as well as Mexico, Taiwan, Hong Kong, and other regions. Collaboration with top IVF doctors globally ensures that your IVF journey proceeds smoothly without obstacles.