How Do Chromosomal Abnormalities Specifically Affect Conception? Third-Generation IVF Assists Healthy Births

2025-04-25 21:59:13，visits： 7

 

As the trend of late marriage and delayed childbearing grows, more families face new challenges when planning their families. A significant issue arising with increasing age is the potential impact of chromosomal abnormalities on fertility. Particularly after the age of 35, the associated risks increase annually, becoming an unignorable hidden danger. How to effectively identify and avoid these issues during the pre-pregnancy stage is a common concern for many families.

 

Within the human body, chromosomes, as carriers of genetic information, bear the responsibility of accurately transmitting genes. Under normal circumstances, each person has 23 pairs of chromosomes, half from each parent. However, due to errors during meiosis, chromosomes may have an extra or missing number, or their structure may undergo rearrangements such as deletions, duplications, or translocations.

 

These abnormalities not only affect the quality of sperm and eggs but can also lead to abnormal embryo development, subsequently causing recurrent miscarriages or pregnancy failure. For men, as age increases, sperm DNA fragmentation rates rise, and the probability of chromosomal abnormalities increases accordingly. For women, egg quality significantly declines after age 35, which also increases the risk of chromosomal abnormalities in embryos.

 

Research shows that women over 35 have a much higher chance of chromosomal abnormalities after pregnancy than younger women, and these types of embryos often cannot continue to develop in the early stages, leading to a significantly increased risk of miscarriage. Therefore, conducting chromosome karyotype analysis or genetic testing during the pre-pregnancy stage can not only predict reproductive risks but also provide a basis for subsequent fertility decisions.

 

Furthermore, for couples with a history of miscarriage, unexplained infertility, or a family history of genetic diseases, such testing is even more necessary. It is not only a crucial part of scientific pregnancy preparation but also a key tool for avoiding the risk of genetic diseases and improving the quality of births.

 

When facing the risk of chromosomal abnormalities, traditional IVF technology struggles to solve the genetic problems of embryos. However, third-generation IVF technology (IVF-PGT, including PGS and PGD) performs genetic diagnosis and chromosome screening before embryo implantation, thereby selecting chromosomally normal embryos for transfer. This technology can significantly reduce the risk of pregnancy failure, early miscarriage, and birth defects caused by chromosomal abnormalities.

Especially for older women or those with multiple previous IVF failures, PGS technology has become one of the important guarantees for improving IVF success rates. It helps doctors accurately assess the health status of each embryo, ensure the quality of transfer, and effectively improve pregnancy rates and healthy live birth rates. Currently, IVF USA provides services such as USA egg freezing and USA IVF to those in need, and its business has expanded beyond the United States to Japan IVF and egg freezing, Thailand IVF and egg freezing, as well as Taiwan and Hong Kong, collaborating closely with global IVF doctors. Dr. Nathan Zhang and his team, with a professional and rigorous attitude, provide personalized solutions for everyone with family planning needs, helping them screen risks from the source and steadily move towards the goal of healthy pregnancy.